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    2025-07-13T18:38:43+00:00

    Nope, E. coli does not have a true nucleus.

    It is a prokaryote, which means its chromosome just sits in a region we call the nucleoid. There is no surrounding double membrane, no nuclear pores, no mitosis. The DNA is still highly organised though, it is supercoiled and held by proteins a bit like histones.

    Because the DNA is open to the cytoplasm, transcription and translation can happen at the same time. That is one of the classic differences between bacteria and the eukaryotic cells that *do* have a nucleus.

    So if you look under an electron microscope you will not see a round dark body like you do in yeast or human cells, only a diffuse more lightly stained area where the chromosome is concentrated.

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