can salmonella cause colitis ?
Question
Kerri M. Cox
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Answer ( 1 )
Enterocolitis is characterized by an invasion of the
epithelial and subepithelial tissue of the small and large
intestines. Strains that do not invade do not cause disease.
The organisms penetrate both through and between the
Mucosal cells into the lamina propria, with resulting
inflammation and diarrhea. Neutrophils limit the infection
to the gut and the adjacent mesenteric lymph nodes; bacteremia is infrequent in enterocolitis. In contrast to Shigella
enterocolitis, in which the infectious dose is very small (on
the order of 100 organisms), the dose of Salmonella
required is much higher, at least 100,000 organisms. Gastric acid is an important host
defense; gastrectomy or use of antacids lowers the infectious dose significantly.