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    E. coli can enter the bloodstream through various routes, typically through breaks in the skin or mucous membranes. For example, if someone has a wound or injury contaminated with E. coli bacteria, the bacteria can enter their bloodstream through the open wound. Additionally, E. coli can also enter the bloodstream through invasive medical procedures, such as surgery or the use of medical devices like catheters or intravenous lines. In some cases, E. coli can also spread from other parts of the body, such as the urinary tract or the gastrointestinal tract, to the bloodstream through a process called bacteremia. Once in the bloodstream, E. coli can cause serious infections, such as sepsis or bacteremia, which require prompt medical attention and treatment with antibiotics.

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