Answer ( 1 )



    salmonella enters through the ingestion and then attach and invade to the microvilli of the GIT then it enter s the distal ileum (payer’s patches). salmonella typhi multiplies within the phagocytic cell. salmonella typhi has Vi capsular antigen that helps to avoid the neutrophil based inflammation as well. intracellular multiplication continues in the cell of the reticuloendothelial system and then done the hypoplastic changes in the lymphoid tissue and due to this done the necrosis, haemorrhages, perforation of the intestinal wall and after that enter the bloodstream through the thoracic duct and cause the infection of gall bladder also. S.typhi continue to multiply until it reaches the critical density i.e. 1,000,000 in order to cause the infection.

    hope you got it.


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